11/7/2023 0 Comments Nocturnal epilepsy temporal lobe![]() Landmark study in the Lingfield epilepsy colony that confirmed circadian peak seizure times and described multidien cycles of seizures with patient-specific periodicity. ![]() Epilepsy: its symptoms, treatment, and relation to other chronic convulsive diseases. Landmark study in the Lingfield epilepsy colony that revealed circadian peak seizure times in nocturnal and diurnal epilepsies. Time of day in relation to convulsions in epilepsy. Epilepsy and other chronic convulsive diseases: their causes, symptoms, & treatment. De l’étiologie de l’épilepsie: et des indications que l’étude des causes peut fournir pour le traitement de cette maladie 94 (Bailliere, 1854). Tome Douzième Contenant le Traité de l’epilepsie (Chez Francois Grasset & Comp., 1784).Įcheverria, M. Œuvres de Monsieur Tissot, Nouvelle Édition. A treatise concerning the influence of the sun and moon upon human bodies, and the diseases thereby produced 36–47 (J. The falling sickness: a history of epilepsy from the Greeks to the beginnings of modern neurology (The Johns Hopkins University Press, 1994). Landmark historical study that revealed periodicity in seizure diaries kept by patients. The periodic features of some seizure states. Translation and analysis of a cuneiform text forming part of a Babylonian treatise on epilepsy. In essence, this Review addresses the broad question of why seizures occur when they occur. The potential clinical applications of a knowledge of cycles in epilepsy, including seizure forecasting and chronotherapy, are discussed in the context of the emerging concept of seizure risk. ![]() We discuss advances in our understanding of the mechanistic underpinnings of these cycles and highlight the knowledge gaps that remain. Here, we review this evidence, synthesizing data from historical observational studies, modern implanted devices, electronic seizure diaries and laboratory-based animal neurophysiology. Chronic recordings of brain activity in humans and in animals have yielded converging evidence for the existence of cycles of epileptic brain activity that operate over diverse timescales: daily (circadian), multi-day (multidien) and yearly (circannual). Observations that seizures are cyclical date back to antiquity, but recent technological advances have, for the first time, enabled cycles of seizure occurrence to be quantitatively characterized with direct brain recordings. A canonical view holds that seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans have looked for patterns of temporal organization in seizure occurrence. Within the TLEs, the nocturnal TLE form seems to have a better surgical prognosis.Epilepsy is among the most dynamic disorders in neurology. Infrequent and nonclustered seizures, rare family history of epilepsy, and low prevalence of childhood febrile convulsions characterize nocturnal TLE. Only two were seizure free on medication. None of these factors differed significantly in the two groups except for higher frequency of the following in the diurnal TLE group compared with the nocturnal TLE group: positive family history for epilepsy (33% versus 8%, p=0.01), estimated frequency of seizures (median, 14 versus 2 per month p 12 months). In the nocturnal TLE group, 2 of 26 patients had a positive family history of epilepsy, 18 reported an aura, 4 presented with CPS in clusters, 11 had unilateral and 15 bilateral temporal EEG abnormalities, and 14 of 21 studied had unilateral mesial temporal atrophy. Mean age at seizure onset was similar for both groups (16.3 versus 18.7 years). Clinical and laboratory characteristics of these individuals were studied and compared with a group of 72 age-matched, randomly selected patients with nonlesional TLE and predominantly diurnal seizures (diurnal TLE). ![]() TLE associated with seizures occurring only or predominantly during sleep (nocturnal TLE) is less common.įrom a series of patients with refractory TLE studied between 19, the authors identified 26 patients (15 men) with nonlesional nocturnal TLE (mean age, 40 years). To analyze clinical, electrophysiologic, and neuroradiologic characteristics and prognostic factors in a group of patients with temporal lobe epilepsy (TLE) and complex partial seizures (CPS) occurring exclusively or predominantly after they fall asleep or before they awaken.ĬPS arising during sleep are classically identified with frontal lobe epilepsy.
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